A Contours series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5-HTP induced head twitches (5-HT2A antagonism) and catalepsy studies in albino mice.The physicochemical similarity of the target compounds with respect to stand

The renewed conflict between Russia and NATO has brought back security concerns over nuclear and conventional deterrence and defence in Europe.Since the days of the Cold War those two elements are closely intertwined, with direct ramifications on arms control policies.This article recalls the post-Cold War history of conventional arms control in Eu

Abstract Background Health-related apps have great potential to enhance health and prevent disease globally, but their quality currently varies too much for clinicians to feel confident about recommending them to patients.The major quality concerns are dubious app content, loss of privacy associated with widespread sharing of the patient data they

Thrust vector control by scarfed nozzle jet can realize attitude control and trajectory adjustment of Country Boots the undersea vehicle and improve the maneuvering performance and stability of the undersea vehicle.In order to investigate the working state of the underwater scarfed nozzle, the Reynolds time-averaged Navier-Stokes(RANS) method and t

Objective: To compare the prevalence and subtypes of childhood maltreatment (CM) between individuals with and without substance use disorder (SUD) and investigate the influence of different traumas on the preferential use of substances and the severity of dependence.Methods: The sample consisted of 1,040 men with SUD (alcohol users [n=315], crack-c